Publications

  1. Forman-Kay, JD, Kriwacki, RW, Seydoux, G. Phase Separation in Biology and Disease. J. Mol. Biol. 2018;430 (23):4603-4606. doi: 10.1016/j.jmb.2018.09.006. PubMed PMID:30213727 .
  2. Folkmann, AW, Seydoux, G. Single-molecule study reveals the frenetic lives of proteins in gradients. Proc. Natl. Acad. Sci. U.S.A. 2018;115 (38):9336-9338. doi: 10.1073/pnas.1812248115. PubMed PMID:30181287 PubMed Central PMC6156616.
  3. Seydoux, G. The P Granules of C. elegans: A Genetic Model for the Study of RNA-Protein Condensates. J. Mol. Biol. 2018;430 (23):4702-4710. doi: 10.1016/j.jmb.2018.08.007. PubMed PMID:30096346 .
  4. Paix, A, Folkmann, A, Goldman, DH, Kulaga, H, Grzelak, MJ, Rasoloson, D et al.. Precision genome editing using synthesis-dependent repair of Cas9-induced DNA breaks. Proc. Natl. Acad. Sci. U.S.A. 2017;114 (50):E10745-E10754. doi: 10.1073/pnas.1711979114. PubMed PMID:29183983 PubMed Central PMC5740635.
  5. Lee, CS, Lu, T, Seydoux, G. Nanos promotes epigenetic reprograming of the germline by down-regulation of the THAP transcription factor LIN-15B. Elife. 2017;6 :. doi: 10.7554/eLife.30201. PubMed PMID:29111977 PubMed Central PMC5734877.
  6. Greider, C, Hopkins, N, Steitz, J, Amon, A, Asai, D, Barres, B et al.. Not just Salk. Science. 2017;357 (6356):1105-1106. doi: 10.1126/science.aao6221. PubMed PMID:28912235 .
  7. Mok, CA, Au, V, Thompson, OA, Edgley, ML, Gevirtzman, L, Yochem, J et al.. MIP-MAP: High-Throughput Mapping of Caenorhabditis elegans Temperature-Sensitive Mutants via Molecular Inversion Probes. Genetics. 2017;207 (2):447-463. doi: 10.1534/genetics.117.300179. PubMed PMID:28827289 PubMed Central PMC5629315.
  8. Paix, A, Folkmann, A, Seydoux, G. Precision genome editing using CRISPR-Cas9 and linear repair templates in C. elegans. Methods. 2017;121-122 :86-93. doi: 10.1016/j.ymeth.2017.03.023. PubMed PMID:28392263 .
  9. Smith, J, Calidas, D, Schmidt, H, Lu, T, Rasoloson, D, Seydoux, G et al.. Spatial patterning of P granules by RNA-induced phase separation of the intrinsically-disordered protein MEG-3. Elife. 2016;5 :. doi: 10.7554/eLife.21337. PubMed PMID:27914198 PubMed Central PMC5262379.
  10. Housden, BE, Muhar, M, Gemberling, M, Gersbach, CA, Stainier, DY, Seydoux, G et al.. Loss-of-function genetic tools for animal models: cross-species and cross-platform differences. Nat. Rev. Genet. 2017;18 (1):24-40. doi: 10.1038/nrg.2016.118. PubMed PMID:27795562 PubMed Central PMC5206767.
  11. Paix, A, Schmidt, H, Seydoux, G. Cas9-assisted recombineering in C. elegans: genome editing using in vivo assembly of linear DNAs. Nucleic Acids Res. 2016;44 (15):e128. doi: 10.1093/nar/gkw502. PubMed PMID:27257074 PubMed Central PMC5009740.
  12. Paix, A, Folkmann, A, Rasoloson, D, Seydoux, G. High Efficiency, Homology-Directed Genome Editing in Caenorhabditis elegans Using CRISPR-Cas9 Ribonucleoprotein Complexes. Genetics. 2015;201 (1):47-54. doi: 10.1534/genetics.115.179382. PubMed PMID:26187122 PubMed Central PMC4566275.
  13. Wang, JT, Smith, J, Chen, BC, Schmidt, H, Rasoloson, D, Paix, A et al.. Regulation of RNA granule dynamics by phosphorylation of serine-rich, intrinsically disordered proteins in C. elegans. Elife. 2014;3 :e04591. doi: 10.7554/eLife.04591. PubMed PMID:25535836 PubMed Central PMC4296509.
  14. Chen, BC, Legant, WR, Wang, K, Shao, L, Milkie, DE, Davidson, MW et al.. Lattice light-sheet microscopy: imaging molecules to embryos at high spatiotemporal resolution. Science. 2014;346 (6208):1257998. doi: 10.1126/science.1257998. PubMed PMID:25342811 PubMed Central PMC4336192.
  15. Paix, A, Wang, Y, Smith, HE, Lee, CY, Calidas, D, Lu, T et al.. Scalable and versatile genome editing using linear DNAs with microhomology to Cas9 Sites in Caenorhabditis elegans. Genetics. 2014;198 (4):1347-56. doi: 10.1534/genetics.114.170423. PubMed PMID:25249454 PubMed Central PMC4256755.
  16. Wang, JT, Seydoux, G. P granules. Curr. Biol. 2014;24 (14):R637-R638. doi: 10.1016/j.cub.2014.06.018. PubMed PMID:25050955 PubMed Central PMC4966529.
  17. Wang, Y, Wang, JT, Rasoloson, D, Stitzel, ML, O' Connell, KF, Smith, HE et al.. Identification of suppressors of mbk-2/DYRK by whole-genome sequencing. G3 (Bethesda). 2014;4 (2):231-41. doi: 10.1534/g3.113.009126. PubMed PMID:24347622 PubMed Central PMC3931558.
  18. Motegi, F, Seydoux, G. The PAR network: redundancy and robustness in a symmetry-breaking system. Philos. Trans. R. Soc. Lond., B, Biol. Sci. 2013;368 (1629):20130010. doi: 10.1098/rstb.2013.0010. PubMed PMID:24062581 PubMed Central PMC3785961.
  19. Seydoux, G. 'Goldilocks' suppressor screen identifies web of polarity regulators. Nat. Cell Biol. 2013;15 (1):9-10. doi: 10.1038/ncb2666. PubMed PMID:23263368 .
  20. Voronina, E, Paix, A, Seydoux, G. The P granule component PGL-1 promotes the localization and silencing activity of the PUF protein FBF-2 in germline stem cells. Development. 2012;139 (20):3732-40. doi: 10.1242/dev.083980. PubMed PMID:22991439 PubMed Central PMC3445306.
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